|Other Names||Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylation of cardiac myosin heavy chains (see MYH7B,MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase,such as MYLK3, potentiates the force and rate of cross-bridgerecruitment in cardiac myocytes (Chan et al., 2008 [PubMed18202317]).
Al-Sadi, R., et al. J. Immunol. 180(8):5653-5661(2008)Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)
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