|Other Names||Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, MYLK3, MLCK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).|
|Tissue Location||Restricted to heart.|
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This gene encodes a member of the tripartite motif (TRIM)family. The TRIM motif includes three zinc-binding domains, a RING,a B-box type 1 and a B-box type 2, and a coiled-coil region. Thisgene is located on chromosome 13 within the minimal deletion regionfor B-cell chronic lymphocytic leukemia. Multiple alternativelyspliced transcript variants have been found for this gene.
Lerner, M., et al. Mol. Biol. Cell 18(5):1670-1682(2007)Skoblov, M., et al. Biochem. Biophys. Res. Commun. 342(3):859-866(2006)Corcoran, M.M., et al. Genes Chromosomes Cancer 40(4):285-297(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)van Everdink, W.J., et al. Cancer Genet. Cytogenet. 146(1):48-57(2003)
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