|Other Names||Potassium channel regulatory protein, Potassium channel regulator, Protein CLLD4, KCNRG, CLLD4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.|
|Cellular Location||Endoplasmic reticulum|
|Tissue Location||Ubiquitous in normal tissues and expressed in some tumor tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a regulatory subunitof the AMP-activated protein kinase (AMPK). AMPK is a heterotrimerconsisting of an alpha catalytic subunit, and non-catalytic betaand gamma subunits. AMPK is an important energy-sensing enzyme thatmonitors cellular energy status. In response to cellular metabolicstresses, AMPK is activated, and thus phosphorylates andinactivates acetyl-CoA carboxylase (ACC) and beta-hydroxybeta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved inregulating de novo biosynthesis of fatty acid and cholesterol. Thissubunit is one of the gamma regulatory subunits of AMPK.Alternatively spliced transcript variants encoding distinctisoforms have been observed.
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Jassim, G., et al. Pharmacopsychiatry (2010) In press :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
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