|Other Names||Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2, PYCR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).|
|Cellular Location||Cytoplasm. Mitochondrion|
|Tissue Location||Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).|
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This gene encodes a member of the Ser/Thr protein kinasefamily and the TGFB receptor subfamily. The encoded protein is atransmembrane protein that has a protein kinase domain, forms aheterodimeric complex with another receptor protein, and bindsTGF-beta. This receptor/ligand complex phosphorylates proteins,which then enter the nucleus and regulate the transcription of asubset of genes related to cell proliferation. Mutations in thisgene have been associated with Marfan Syndrome, Loeys-Deitz AorticAneurysm Syndrome, and the development of various types of tumors.Alternatively spliced transcript variants encoding differentisoforms have been characterized.
Inamoto, S., et al. Cardiovasc. Res. 88(3):520-529(2010)Bianchini, G., et al. J. Clin. Oncol. 28(28):4316-4323(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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