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STK36 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NRP7
Clone Names 101008159
Peptide ID 101008159
Additional Information
Gene ID 27148
Other Names Serine/threonine-protein kinase 36, Fused homolog, STK36 {ECO:0000312|EMBL:AAH261581}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK36 {ECO:0000312|EMBL:AAH26158.1}
Function Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.
Cellular Location Cytoplasm. Nucleus. Note=Low levels also present in the nucleus.
Tissue Location Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
Research Areas
Citations (0)

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This gene encodes the alpha 2 chain of type VIII collagen.The protein is a major component of the basement membrane of thecorneal endothelium and forms homo- or heterotrimers with alpha 1(VIII) type collagens. Defects in this gene are associated withFuchs endothelial corneal dystrophy and posterior polymorphouscorneal dystrophy type 2.


Hemadevi, B., et al. BMC Ophthalmol 10, 3 (2010) :Afshari, N.A., et al. Invest. Ophthalmol. Vis. Sci. 50(3):1093-1097(2009)Liskova, P., et al. Br J Ophthalmol 91(12):1717-1718(2007)Aldave, A.J., et al. Cornea 26(8):963-965(2007)Zhang, C., et al. Trans Am Ophthalmol Soc 104, 85-97 (2006) :

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$ 80.00
Cat# BP11857a
Availability: In Stock
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