|Other Names||Collagen alpha-1(XIII) chain, COLXIIIA1, COL13A1 (HGNC:2190)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. Isoform 10: Expressed in muscle (PubMed:26626625).|
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IRF1 encodes interferon regulatory factor 1, a member ofthe interferon regulatory transcription factor (IRF) family. IRF1serves as an activator of interferons alpha and beta transcription,and in mouse it has been shown to be required for double-strandedRNA induction of these genes. IRF1 also functions as atranscription activator of genes induced by interferons alpha,beta, and gamma. Further, IRF1 has been shown to play roles inregulating apoptosis and tumor-suppressoion.
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Matsuzaki, S., et al. J. Immunol. 185(8):4863-4872(2010)Antonios, D., et al. J. Immunol. 185(1):89-98(2010)Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):255-258(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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