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TRIM28 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13263
Clone Names 6030103
Peptide ID 6030103
Additional Information
Gene ID 10155
Other Names Transcription intermediary factor 1-beta, TIF1-beta, E3 SUMO-protein ligase TRIM28, 632-, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28, TRIM28, KAP1, RNF96, TIF1B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM28
Synonyms KAP1, RNF96, TIF1B
Function Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754).
Cellular Location Nucleus Note=Associated with centromeric heterochromatin during cell differentiation through CBX1.
Tissue Location Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Research Areas
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The protein encoded by this gene mediates transcriptionalcontrol by interaction with the Kruppel-associated box repressiondomain found in many transcription factors. The protein localizesto the nucleus and is thought to associate with specific chromatinregions. The protein is a member of the tripartite motif family.This tripartite motif includes three zinc-binding domains, a RING,a B-box type 1 and a B-box type 2, and a coiled-coil region.


Lai, I.L., et al. J. Biol. Chem. 285(10):7187-7196(2010)Yokoe, T., et al. Ann. Surg. Oncol. 17(3):821-828(2010)Noon, A.T., et al. Nat. Cell Biol. 12(2):177-184(2010)Li, X., et al. Sci Signal 3 (119), RA32 (2010) :Groner, A.C., et al. PLoS Genet. 6 (3), E1000869 (2010) :

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$ 80.00
Cat# BP11866a
(40 western blots)
Availability: In Stock
Bulk Size
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