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GAS1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P54826
Clone Names 71213109
Peptide ID 71213109
Additional Information
Other Names Growth arrest-specific protein 1, GAS-1, GAS1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAS1
Function Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor EMBL; L13698; AAA72368.1; -; mRNA EMBL; AL158149; CAH71308.1; -; Genomic_DNA EMBL; BC074908; AAH74908.1; -; mRNA EMBL; BC074809; AAH74809.1; -; mRNA EMBL; BC132682; AAI32683.1; -; mRNA EMBL; BC136586; AAI36587.1; -; mRNA CCDS; CCDS6674.1; - PIR; A53138; A53138 RefSeq; NP_002039.2; NM_002048.2 UniGene; Hs.65029; - ProteinModelPortal; P54826; - BioGrid; 108889; 2 STRING; 9606.ENSP00000298743; - iPTMnet; P54826; - PhosphoSitePlus; P54826; - BioMuta; GAS1; - DMDM; 218512049; - MaxQB; P54826; - PaxDb; P54826; - PeptideAtlas; P54826; - PRIDE; P54826; - Ensembl; ENST00000298743; ENSP00000298743; ENSG00000180447 GeneID; 2619; - KEGG; hsa:2619; - UCSC; uc004aox.5; human CTD; 2619; - DisGeNET; 2619; - GeneCards; GAS1; - H-InvDB; HIX0034867; - HGNC; HGNC:4165; GAS1 HPA; CAB024164; - HPA; HPA066902; - MalaCards; GAS1; - MIM; 139185; gene neXtProt; NX_P54826; - OpenTargets; ENSG00000180447; - Orphanet; 93925; Alobar holoprosencephaly Orphanet; 93924; Lobar holoprosencephaly Orphanet; 280200; Microform holoprosencephaly Orphanet; 93926; Midline interhemispheric variant of holoprosencephaly Orphanet; 220386; Semilobar holoprosencephaly Orphanet; 280195; Septopreoptic holoprosencephaly PharmGKB; PA28578; - eggNOG; ENOG410IW52; Eukaryota eggNOG; ENOG4111JS0; LUCA GeneTree; ENSGT00390000001195; - HOGENOM; HOG000233688; - HOVERGEN; HBG005804; - InParanoid; P54826; - KO; K06232; - OMA; CWQALLQ; - OrthoDB; EOG091G0MBW; - PhylomeDB; P54826; - TreeFam; TF329660; - BioCyc; ZFISH:ENSG00000180447-MONOMER; - Reactome; R-HSA-5632681; Ligand-receptor interactions Reactome; R-HSA-5635838; Activation of SMO SignaLink; P54826; - GeneWiki; GAS1; - GenomeRNAi; 2619; - PRO; PR:P54826; - Proteomes; UP000005640; Chromosome 9 Bgee; ENSG00000180447; - CleanEx; HS_GAS1; - Genevisible; P54826; HS GO; GO:0046658; C:anchored component of plasma membrane; ISS:UniProtKB GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW GO; GO:0045165; P:cell fate commitment; ISS:UniProtKB GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEP:UniProtKB GO; GO:0048589; P:developmental growth; ISS:UniProtKB GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB GO; GO:0010955; P:negative regulation of protein processing; IMP:UniProtKB GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IMP:UniProtKB GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB InterPro; IPR016017; GDNF/GAS1 Pfam; PF02351; GDNF; 1 SMART; SM00907; GDNF; 2 2: Evidence at transcript level; Cell cycle; Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; Growth arrest; Lipoprotein; Membrane; Reference proteome; Signal SIGNAL 1 39 CHAIN 40 318 Growth arrest-specific protein 1 /FTId=PRO_0000021318 PROPEP 319 345 Removed in mature form. /FTId=PRO_0000021319 COMPBIAS 87 91 Poly-Ala COMPBIAS 285 288 Poly-Asp COMPBIAS 319 322 Poly-Gly COMPBIAS 337 341 Poly-Leu LIPID 318 318 GPI-anchor amidated serine CARBOHYD 117 117 N-linked (GlcNAc...). CONFLICT 216 216 A -> V (in Ref. 1; AAA72368) SEQUENCE 345 AA; 35693 MW; 31A0CBEEC3632F82 CRC64; MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF
Research Areas
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Background

Growth arrest-specific 1 plays a role in growthsuppression. GAS1 blocks entry to S phase and prevents cycling ofnormal and transformed cells. Gas1 is a putative tumor suppressorgene.

References

Ribeiro, L.A., et al. Am. J. Med. Genet. A 152A (7), 1688-1694 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Rittie, L., et al. Aging Cell 8(6):738-751(2009)Zhao, L., et al. J. Biol. Chem. 284(39):26273-26285(2009)Dominguez-Monzon, G., et al. Int. J. Dev. Neurosci. 27(4):305-313(2009)

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$ 80.00
Cat# BP11869a
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