|Other Names||F-box/WD repeat-containing protein 1A, E3RSIkappaB, Epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, pIkappaBalpha-E3 receptor subunit, BTRC, BTRCP, FBW1A, FBXW1A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BTRCP, FBW1A, FBXW1A|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in epididymis (at protein level).|
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This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbws class; in addition to an F-box, this protein containsmultiple WD-40 repeats. This protein is homologous to XenopusbTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimbproteins. It interacts with HIV-1 Vpu and connects CD4 to theproteolytic machinery. It also associates specifically withphosphorylated IkappaBalpha and beta-catenin destruction motifs,probably functioning in multiple transcriptional programs byactivating the NF-kappaB pathway and inhibiting the beta-cateninpathway.
Popov, N., et al. Nat. Cell Biol. 12(10):973-981(2010)Inuzuka, H., et al. Cancer Cell 18(2):147-159(2010)Guderian, G., et al. J. Cell. Sci. 123 (PT 13), 2163-2169 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tsai, W.B., et al. PLoS ONE 5 (7), E11171 (2010) :
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