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GHSR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92847 |
|---|---|
| Clone Names | 80325154 |
| Gene ID | 2693 |
|---|---|
| Other Names | Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, GHRP, Ghrelin receptor, GHSR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GHSR |
|---|---|
| Function | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Pituitary and hypothalamus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the G-protein coupledreceptor family. The encoded protein may play a role in energyhomeostasis and regulation of body weight. Two identifiedtranscript variants are expressed in several tissues and areevolutionary conserved in fish and swine. One transcript, 1a,excises an intron and encodes the functional protein; this proteinis the receptor for the Ghrelin ligand and defines a neuroendocrinepathway for growth hormone release. The second transcript (1b)retains the intron and does not function as a receptor for Ghrelin;however, it may function to attenuate activity of isoform 1a.Mutations in this gene are associated with autosomal idiopathicshort stature.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Landgren, S., et al. Alcohol. Clin. Exp. Res. 34(9):1519-1524(2010)Aghajanova, L., et al. Reprod Sci 17(9):823-832(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
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