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IRF9 Antibody (N-term) Blocking PeptidesSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP11875a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
IRF9 Antibody (N-term) Blocking Peptides - Product info | |
| Primary Accession | Q00978 |
| Clone Names | 80513053 |
| Calculated MW | 43696 Da |
IRF9 Antibody (N-term) Blocking Peptides - Additional info | |
| Gene ID 10379 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
IRF9 Antibody (N-term) Blocking Peptides - Protein Information | |
| Name IRF9 | |
| Synonyms ISGF3G | |
| Function Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2 The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state | |
| Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta | |
IRF9 Antibody (N-term) Blocking Peptides - Research Areas
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BACKGROUND
IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
REFERENCES
Maiwald, T., et al. FEBS J. 277(22):4741-4754(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Watanabe, T., et al. J. Clin. Invest. 120(5):1645-1662(2010)Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
