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NOD2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HC29
Clone Names 90713150
Peptide ID 90713150
Additional Information
Gene ID 64127
Other Names Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOD2
Synonyms CARD15, IBD1
Function Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
Cellular Location Cytoplasm. Membrane. Basolateral cell membrane
Tissue Location Monocytes-specific.
Research Areas
Citations (0)

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Background

This gene is a member of the Nod1/Apaf-1 family andencodes a protein with two caspase recruitment (CARD) domains andsix leucine-rich repeats (LRRs). The protein is primarily expressedin the peripheral blood leukocytes. It plays a role in the immuneresponse to intracellular bacterial lipopolysaccharides (LPS) byrecognizing the muramyl dipeptide (MDP) derived from them andactivating the NFKB protein. Mutations in this gene have beenassociated with Crohn disease and Blau syndrome. [provided byRefSeq].

References

Sehgal, R., et al. Dis. Colon Rectum 53(11):1487-1494(2010)Cadwell, K. Gastroenterology 139(5):1448-1450(2010)Lacher, M., et al. J. Pediatr. Surg. 45(8):1591-1597(2010)Kramer, M., et al. BMC Res Notes 3, 224 (2010) :Kanazawa, N., et al. Blood 105(3):1195-1197(2005)

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$ 80.00
Cat# BP11885c
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