|Other Names||Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).|
|Cellular Location||Cytoplasm. Membrane. Basolateral cell membrane|
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This gene is a member of the Nod1/Apaf-1 family andencodes a protein with two caspase recruitment (CARD) domains andsix leucine-rich repeats (LRRs). The protein is primarily expressedin the peripheral blood leukocytes. It plays a role in the immuneresponse to intracellular bacterial lipopolysaccharides (LPS) byrecognizing the muramyl dipeptide (MDP) derived from them andactivating the NFKB protein. Mutations in this gene have beenassociated with Crohn disease and Blau syndrome. [provided byRefSeq].
Sehgal, R., et al. Dis. Colon Rectum 53(11):1487-1494(2010)Cadwell, K. Gastroenterology 139(5):1448-1450(2010)Lacher, M., et al. J. Pediatr. Surg. 45(8):1591-1597(2010)Kramer, M., et al. BMC Res Notes 3, 224 (2010) :Kanazawa, N., et al. Blood 105(3):1195-1197(2005)
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