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PRSS3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35030 |
|---|---|
| Clone Names | 101008129 |
| Gene ID | 5646 |
|---|---|
| Other Names | Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV, PRSS3, PRSS4, TRY3, TRY4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRSS3 |
|---|---|
| Synonyms | PRSS4, TRY3, TRY4 |
| Function | Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. |
| Cellular Location | Secreted. |
| Tissue Location | Detected in pancreas and pancreatic fluid (at protein level) (PubMed:6698368). Expressed in pancreas and brain (PubMed:8294000). Detected in ileum (PubMed:12021776) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a trypsinogen, which is a member of thetrypsin family of serine proteases. This enzyme is expressed in thebrain and pancreas and is resistant to common trypsin inhibitors.It is active on peptide linkages involving the carboxyl group oflysine or arginine. This gene is localized to the locus of T cellreceptor beta variable orphans on chromosome 9. Four transcriptvariants encoding different isoforms have been described for thisgene.
References
Jiang, G., et al. Gut 59(11):1535-1544(2010)Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)Salameh, M.A., et al. J. Biol. Chem. 285(3):1939-1949(2010)Rosendahl, J., et al. Pancreatology 10 (2-3), 243-249 (2010) :Koistinen, H., et al. Neuroscience 160(1):97-102(2009)
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