|Other Names||Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related gene potassium channel 2, ERG-2, Eag-related protein 2, Ether-a-go-go-related protein 2, hERG-2, hERG2, Voltage-gated potassium channel subunit Kv112, KCNH6, ERG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in prolactin-secreting adenomas.|
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Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium channel, voltage-gated, subfamily H. This member is apore-forming (alpha) subunit. Several alternatively splicedtranscript variants have been identified from this gene, but thefull-length nature of only two transcript variants has beendetermined.
Liu, B.C., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(3):506-509(2010)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Bauer, C.K., et al. Pflugers Arch. 445(5):589-600(2003)Ganetzky, B., et al. Ann. N. Y. Acad. Sci. 868, 356-369 (1999) :
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