|Other Names||SHC-transforming protein 4, Rai-like protein, RaLP, SHC-transforming protein D, hShcD, Src homology 2 domain-containing-transforming protein C4, SH2 domain protein C4, SHC4, SHCD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction.|
|Tissue Location||Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.|
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SHC4 activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
You, Y., et al. BMB Rep 43(7):485-490(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jones, N., et al. Mol. Cell. Biol. 27(13):4759-4773(2007)Fagiani, E., et al. Cancer Res. 67(7):3064-3073(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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