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TUBB2B Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BVA1 |
|---|---|
| Clone Names | 101008068 |
| Gene ID | 347733 |
|---|---|
| Other Names | Tubulin beta-2B chain, TUBB2B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TUBB2B |
|---|---|
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:28013290, PubMed:26732629). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | High expression in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a beta isoform oftubulin, which binds GTP and is a major component of microtubules.This gene is highly similar to TUBB2A and TUBB2C. Defects in thisgene are a cause of asymmetric polymicrogyria. [provided byRefSeq].
References
Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)Jaglin, X.H., et al. Nat. Genet. 41(6):746-752(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Cucchiarelli, V., et al. Cell Motil. Cytoskeleton 65(8):675-685(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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