|Other Names||Tubulin beta-2B chain, TUBB2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||High expression in brain.|
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The protein encoded by this gene is a beta isoform oftubulin, which binds GTP and is a major component of microtubules.This gene is highly similar to TUBB2A and TUBB2C. Defects in thisgene are a cause of asymmetric polymicrogyria. [provided byRefSeq].
Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)Jaglin, X.H., et al. Nat. Genet. 41(6):746-752(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Cucchiarelli, V., et al. Cell Motil. Cytoskeleton 65(8):675-685(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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