|Other Names||Zinc finger protein 384, CAG repeat protein 1, CAS-interacting zinc finger protein, Nuclear matrix transcription factor 4, Nuclear matrix protein 4, Trinucleotide repeat-containing gene 1 protein, ZNF384, CAGH1, CIZ, NMP4, TNRC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAGH1, CIZ, NMP4, TNRC1|
|Function||Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity).|
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This gene contains long CAG trinucleotide repeats codingconsecutive glutamine residues. The gene product may functions as atranscription factor, with a potential role in the regulation ofneurodevelopment or neuroplasticity. The protein appears to bindand regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Studiesin mouse suggest that nuclear matrix transcription factors(NP/NMP4) may be part of a general mechanical pathway that couplescell construction and function during extracellular matrixremodeling. Multiple transcript variants encoding several isoformshave been found for this gene.
Alves, J., et al. Biochem. Biophys. Res. Commun. 384(4):495-500(2009)Zhong, C.H., et al. Leukemia 22(4):723-729(2008)Janssen, H., et al. Exp. Cell Res. 312(7):1194-1204(2006)La Starza, R., et al. Leukemia 19(9):1696-1699(2005)Martini, A., et al. Cancer Res. 62(19):5408-5412(2002)
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