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CD8B1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P10966
Clone Names 70730010
Peptide ID 70730010
Additional Information
Gene ID 926
Other Names T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD8B
Synonyms CD8B1
Function Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein Isoform 7: Secreted.
Tissue Location Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
Research Areas
Citations (0)

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The CD8 antigen is a cell surface glycoprotein found onmost cytotoxic T lymphocytes that mediates efficient cell-cellinteractions within the immune system. The CD8 antigen, acting as acoreceptor, and the T-cell receptor on the T lymphocyte recognizeantigens displayed by an antigen presenting cell (APC) in thecontext of class I MHC molecules. The functional coreceptor iseither a homodimer composed of two alpha chains, or a heterodimercomposed of one alpha and one beta chain. Both alpha and betachains share significant homology to immunoglobulin variable lightchains. This gene encodes the CD8 beta chain isoforms. Multiplealternatively spliced transcript variants encoding distinctmembrane associated or secreted isoforms have been described. Apseudogene, also located on chromosome 2, has been identified.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chen, M.L., et al. Eur. J. Immunol. 39(12):3423-3435(2009)Thakral, D., et al. J. Immunol. 180(11):7431-7442(2008)Stove, V., et al. J. Virol. 79(17):11422-11433(2005)Moody, A.M., et al. J. Biol. Chem. 278(9):7240-7246(2003)

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$ 80.00
Cat# BP11957b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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