|Other Names||Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
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Provided below are standard protocols that you may find useful for product applications.
POSTN binds to heparin. It induces cell attachment and spreading and plays a role in cell adhesion and may play a role in extracellular matrix mineralization.
Zhu, M., et al. Gynecol. Oncol. 119(2):337-344(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Takada, M., et al. Biochem. Biophys. Res. Commun. 399(2):221-226(2010)Sidhu, S.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14170-14175(2010)Tischler, V., et al. BMC Cancer 10, 273 (2010) :
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