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TRADD Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15628
Clone Names 80821054
Peptide ID 80821054
Additional Information
Gene ID 8717
Other Names Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Location Found in all examined tissues.
Research Areas
Citations (0)

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The protein encoded by this gene is a death domaincontaining adaptor molecule that interacts with TNFRSF1A/TNFR1 andmediates programmed cell death signaling and NF-kappaB activation.This protein binds adaptor protein TRAF2, reduces the recruitmentof inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thussuppresses TRAF2 mediated apoptosis. This protein can also interactwith receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and isinvolved in the Fas-induced cell death pathway. [provided byRefSeq].


Pointon, J.J., et al. Ann. Rheum. Dis. 69(6):1243-1246(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009)Dagle, J.M., et al. Pediatrics 123(4):1116-1123(2009)

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$ 80.00
Cat# BP11963c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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