|Other Names||RNA-binding protein Musashi homolog 1, Musashi-1, MSI1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.|
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This gene encodes a protein containing two conservedtandem RNA recognition motifs. Similar proteins in other speciesfunction as RNA-binding proteins and play central roles inposttranscriptional gene regulation. Expression of this gene hasbeen correlated with the grade of the malignancy and proliferativeactivity in gliomas and melanomas. A pseudogene for this gene islocated on chromosome 11q13.
Fan, L.F., et al. Int J Colorectal Dis 25(1):17-23(2010)de Sousa Abreu, R., et al. J. Biol. Chem. 284(18):12125-12135(2009)Murayama, M., et al. J. Gastroenterol. 44(3):173-182(2009)Gotte, M., et al. J. Pathol. 215(3):317-329(2008)Sanchez-Diaz, P.C., et al. BMC Cancer 8, 280 (2008) :
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