|Other Names||Beta-synuclein, SNCB|
|Target/Specificity||The synthetic peptide sequence is selected from aa 85-97 of HUMAN SNCB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.|
|Tissue Location||Expressed predominantly in brain; concentrated in presynaptic nerve terminals|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Nishioka, K., et al. Arch. Neurol. 67(8):970-975(2010)
Ye, Q., et al. Oncol. Rep. 23(2):429-436(2010)
Rivers, R.C., et al. Protein Sci. 17(5):887-898(2008)
Salem, S.A., et al. Brain Res. 1170, 103-111 (2007) :
Lee, J., et al. Protein Pept. Lett. 14(10):1021-1026(2007)
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