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RAD54 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92698 |
|---|---|
| Clone Names | 81201023 |
| Gene ID | 8438 |
|---|---|
| Other Names | DNA repair and recombination protein RAD54-like, 364-, RAD54 homolog, hHR54, hRAD54, RAD54L, RAD54A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAD54L |
|---|---|
| Synonyms | RAD54A |
| Function | Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:9774452, PubMed:24798879, PubMed:32457312, PubMed:11459989, PubMed:12205100, PubMed:27264870). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the DEAD-likehelicase superfamily, and shares similarity with Saccharomycescerevisiae Rad54, a protein known to be involved in the homologousrecombination and repair of DNA. This protein has been shown toplay a role in homologous recombination related repair of DNAdouble-strand breaks. The binding of this protein to double-strandDNA induces a DNA topological change, which is thought tofacilitate homologous DNA paring, and stimulate DNA recombination.Alternative splicing results in multiple transcript variantsencoding the same protein.
References
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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