|Other Names||DNA repair and recombination protein RAD54-like, 364-, RAD54 homolog, hHR54, hRAD54, RAD54L, RAD54A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the DEAD-likehelicase superfamily, and shares similarity with Saccharomycescerevisiae Rad54, a protein known to be involved in the homologousrecombination and repair of DNA. This protein has been shown toplay a role in homologous recombination related repair of DNAdouble-strand breaks. The binding of this protein to double-strandDNA induces a DNA topological change, which is thought tofacilitate homologous DNA paring, and stimulate DNA recombination.Alternative splicing results in multiple transcript variantsencoding the same protein.
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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