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Synthetic peptide
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| Primary Accession | A6ND01 |
|---|---|
| Clone Names | 100309249 |
| Peptide ID | 100309249 |
| Gene ID | 390243 |
|---|---|
| Other Names | Sperm-egg fusion protein Juno, Folate receptor 4, Folate receptor delta, FR-delta, IZUMO1 receptor protein JUNO, IZUMO1R (HGNC:32565), FOLR4, JUNO |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IZUMO1R (HGNC:32565) |
|---|---|
| Synonyms | FOLR4, JUNO |
| Function | Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9EQF4}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI-anchored at the oolemma {ECO:0000250|UniProtKB:Q9EQF4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Folate receptor 4 is a highly expressed cell surface marker of regulatory T cells.
References
Spiegelstein, O., et al. Gene 258 (1-2), 117-125 (2000) :
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