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OTOP1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7RTM1
Clone Names 100311013
Additional Information
Gene ID 133060
Other Names Otopetrin-1, OTOP1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OTOP1 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19656}
Function Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium {ECO:0000250|UniProtKB:Q80VM9}
Research Areas
Citations (0)
citation

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Background

OTOP1 is required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity).

References

Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)

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$ 277.78
Cat# BP11995c
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