RAB40AL Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P0C0E4 |
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Other Accession | Q8WXH6, NP_001027004.1 |
Gene ID | 282808 |
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Other Names | Ras-related protein Rab-40A-like, Ras-like GTPase, RAB40AL, RLGP |
Target/Specificity | The synthetic peptide sequence is selected from aa 22-36 of HUMAN RAB40AL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RAB40AL |
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Synonyms | RLGP |
Function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Cellular Location | Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Mitochondrion |
Tissue Location | Expressed in brain, lung, heart, skeletal muscle, kidney and liver. Highest expression in brain. Expressed in fetal brain and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy.
References
Saito-Ohara, F., et al. Am. J. Hum. Genet. 71(3):637-645(2002) Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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