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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PCDHB13 Antibody (Center) Blocking peptide   

PCDHB13 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y5F0
Clone Names 101008069
Peptide ID 101008069
Additional Information
Other Names Protocadherin beta-13, PCDH-beta-13, PCDHB13
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB13
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein EMBL; AF152492; AAD43753.1; -; mRNA EMBL; AF217745; AAK51613.1; -; mRNA EMBL; AY358427; AAQ88793.1; -; mRNA EMBL; AK292821; BAF85510.1; -; mRNA EMBL; BC033068; AAH33068.1; -; mRNA EMBL; BC051348; AAH51348.1; -; mRNA EMBL; BC071934; AAH71934.1; -; mRNA CCDS; CCDS4255.1; - RefSeq; NP_061756.1; NM_018933.3 UniGene; Hs.283803; - ProteinModelPortal; Q9Y5F0; - SMR; Q9Y5F0; - BioGrid; 121063; 2 STRING; 9606.ENSP00000345491; - iPTMnet; Q9Y5F0; - PhosphoSitePlus; Q9Y5F0; - BioMuta; PCDHB13; - DMDM; 13431381; - EPD; Q9Y5F0; - MaxQB; Q9Y5F0; - PaxDb; Q9Y5F0; - PeptideAtlas; Q9Y5F0; - PRIDE; Q9Y5F0; - ProteomicsDB; 86349; - Ensembl; ENST00000341948; ENSP00000345491; ENSG00000187372 GeneID; 56123; - KEGG; hsa:56123; - UCSC; uc003lja.3; human CTD; 56123; - EuPathDB; HostDB:ENSG00000187372.11; - GeneCards; PCDHB13; - HGNC; HGNC:8684; PCDHB13 MIM; 604967; gene MIM; 606339; gene neXtProt; NX_Q9Y5F0; - OpenTargets; ENSG00000187372; - PharmGKB; PA33029; - eggNOG; KOG3594; Eukaryota eggNOG; ENOG410XQHI; LUCA GeneTree; ENSGT00920000148964; - HOGENOM; HOG000220892; - HOVERGEN; HBG054878; - InParanoid; Q9Y5F0; - KO; K16494; - OMA; HVVTHNR; - OrthoDB; EOG091G024L; - PhylomeDB; Q9Y5F0; - TreeFam; TF332299; - GeneWiki; PCDHB13; - GenomeRNAi; 56123; - PRO; PR:Q9Y5F0; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000187372; - CleanEx; HS_PCDHB13; - Genevisible; Q9Y5F0; HS GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB GO; GO:0007155; P:cell adhesion; IBA:GO_Central GO; GO:0007268; P:chemical synaptic transmission; TAS:UniProtKB GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro GO; GO:0007416; P:synapse assembly; TAS:UniProtKB InterPro; IPR002126; Cadherin InterPro; IPR015919; Cadherin-like InterPro; IPR032455; Cadherin_C InterPro; IPR020894; Cadherin_CS InterPro; IPR013164; Cadherin_N Pfam; PF00028; Cadherin; 5 Pfam; PF08266; Cadherin_2; 1 Pfam; PF16492; Cadherin_C_2; 1 PRINTS; PR00205; CADHERIN SMART; SM00112; CA; 6 SUPFAM; SSF49313; SSF49313; 5 PROSITE; PS00232; CADHERIN_1; 5 PROSITE; PS50268; CADHERIN_2; 5 2: Evidence at transcript level; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 28 CHAIN 29 798 Protocadherin beta-13 /FTId=PRO_0000003938 TOPO_DOM 29 690 Extracellular. TRANSMEM 691 711 Helical. TOPO_DOM 712 798 Cytoplasmic. DOMAIN 36 134 Cadherin 1. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 139 243 Cadherin 2. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 248 348 Cadherin 3. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 353 451 Cadherin 4. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 456 561 Cadherin 5. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 568 671 Cadherin 6. {ECO:0000255|PROSITE- ProRule:PRU00043} CARBOHYD 418 418 N-linked (GlcNAc...) asparagine CARBOHYD 436 436 N-linked (GlcNAc...) asparagine CARBOHYD 567 567 N-linked (GlcNAc...) asparagine VARIANT 471 471 R -> G (in dbSNP:rs2910329) /FTId=VAR_059189 CONFLICT 705 705 V -> E (in Ref. 4; BAF85510) SEQUENCE 798 AA; 87552 MW; 2A478554498B41A3 CRC64; MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA KDLGLEQREF SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT EPCVLRFQVL LESPFEFFQA ELQVIDINDH SPVFLDKQML VKVSESSPPG TTFPLKNAED LDVGQNNIEN YIISPNSYFR VLTRKRSDGR KYPELVLDKA LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVLDVNDNA PEFEQPFYRV QISEDSPVGF LVVKVSATDV DTGVNGEISY SLFQASEEIG KTFKINPLTG EIELKKQLDF EKLQSYEVNI EARDAGTFSG KCTVLIQVID VNDHAPEVTM SAFTSPIPEN APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSAENF YTLLTERPLD RESRAEYNIT ITVTDLGTPM LITQLNMTVL IADVNDNAPA FTQTSYTLFV RENNSPALHI RSVSATDRDS GTNAQVTYSL LPPQDPHLPL TSLVSINADN GHLFALRSLD YEALQGFQFR VGASDHGSPA LSSEALVRVV VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT ELGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV LLVDGFSQPY LPLPEAAPTQ AQADLLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA SVGRCLVPEG PLPGHLVDMS GTRTLSQSYQ YEVCLAGGSG TNEFKFLKPI IPNFPPQCPG KEIQGNSTFP NNFGFNIQ
Research Areas
Citations (0)

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Background

This gene is a member of the protocadherin beta genecluster, one of three related gene clusters tandemly linked onchromosome five. The gene clusters demonstrate an unusual genomicorganization similar to that of B-cell and T-cell receptor geneclusters. The beta cluster contains 16 genes and 3 pseudogenes,each encoding 6 extracellular cadherin domains and a cytoplasmictail that deviates from others in the cadherin superfamily. Theextracellular domains interact in a homophilic manner to specifydifferential cell-cell connections. Unlike the alpha and gammaclusters, the transcripts from these genes are made up of only onelarge exon, not sharing common 3' exons as expected. These neuralcadherin-like cell adhesion proteins are integral plasma membraneproteins. Their specific functions are unknown but they most likelyplay a critical role in the establishment and function of specificcell-cell neural connections.

References

Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Frank, M., et al. Curr. Opin. Cell Biol. 14(5):557-562(2002)Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)

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$ 80.00
Cat# BP12020c
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