|Other Names||Tubulin-specific chaperone A, TCP1-chaperonin cofactor A, Tubulin-folding cofactor A, CFA, TBCA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is one of four proteins(cofactors A, D, E, and C) involved in the pathway leading tocorrectly folded beta-tubulin from folding intermediates. CofactorsA and D are believed to play a role in capturing and stabilizingbeta-tubulin intermediates in a quasi-native confirmation. CofactorE binds to the cofactor D/beta-tubulin complex; interaction withcofactor C then causes the release of beta-tubulin polypeptidesthat are committed to the native state. This gene encodeschaperonin cofactor A.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)Nolasco, S., et al. FEBS Lett. 579(17):3515-3524(2005)Guasch, A., et al. J. Mol. Biol. 318(4):1139-1149(2002)
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