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IFT57 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NWB7 |
|---|---|
| Clone Names | 101008106 |
| Gene ID | 55081 |
|---|---|
| Other Names | Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFT57 |
|---|---|
| Synonyms | DERP8, ESRRBL1, HIPPI |
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'- AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q8BXG3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5EA95}. Note=Concentrates within the inner segment of cilia. |
| Tissue Location | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
IFT57 is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
References
Gdynia, G., et al. Apoptosis 13(3):437-447(2008)Majumder, P., et al. Biochem. Biophys. Res. Commun. 353(1):80-85(2007)Banerjee, M., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (PT 12), 1247-1250 (2006) :Majumder, P., et al. Neurobiol. Dis. 22(2):242-256(2006)Fan, Y., et al. Nat. Genet. 36(9):989-993(2004)
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