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B3GAT3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O94766 |
|---|---|
| Clone Names | 101008124 |
| Gene ID | 26229 |
|---|---|
| Other Names | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, Beta-1, 3-glucuronyltransferase 3, Glucuronosyltransferase I, GlcAT-I, UDP-GlcUA:Gal beta-1, 3-Gal-R glucuronyltransferase, GlcUAT-I, B3GAT3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | B3GAT3 |
|---|---|
| Function | Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate- glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network |
| Tissue Location | Ubiquitous (but weakly expressed in all tissues examined) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theglucuronyltransferase gene family, enzymes that exhibit strictacceptor specificity, recognizing nonreducing terminal sugars andtheir anomeric linkages. This gene product catalyzes the formationof the glycosaminoglycan-protein linkage by way of a glucuronyltransfer reaction in the final step of the biosynthesis of thelinkage region of proteoglycans.
References
Tone, Y., et al. J. Biol. Chem. 283(24):16801-16807(2008)Fondeur-Gelinotte, M., et al. Glycobiology 17(8):857-867(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Gulberti, S., et al. J. Biol. Chem. 280(2):1417-1425(2005)Venkatesan, N., et al. Proc. Natl. Acad. Sci. U.S.A. 101(52):18087-18092(2004)
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