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AXIN1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O15169
Clone Names 101008209
Peptide ID 101008209
Additional Information
Gene ID 8312
Other Names Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AXIN1
Synonyms AXIN
Function Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Cellular Location Cytoplasm. Nucleus. Membrane. Cell membrane. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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This gene encodes a cytoplasmic protein which contains aregulation of G-protein signaling (RGS) domain and a dishevelledand axin (DIX) domain. The encoded protein interacts withadenomatosis polyposis coli, catenin beta-1, glycogen synthasekinase 3 beta, protein phosphate 2, and itself. This proteinfunctions as a negative regulator of the wingless-type MMTVintegration site family, member 1 (WNT) signaling pathway and caninduce apoptosis. The crystal structure of a portion of thisprotein, alone and in a complex with other proteins, has beenresolved. Mutations in this gene have been associated withhepatocellular carcinoma, hepatoblastomas, ovarian endometriodadenocarcinomas, and medullablastomas. Two transcript variantsencoding distinct isoforms have been identified for this gene.


Sue Ng, S., et al. Biol. Chem. 391 (2-3), 171-180 (2010) :Yang, L.H., et al. Mol. Cancer 9, 25 (2010) :Wooten, E.C., et al. PLoS ONE 5 (1), E8830 (2010) :Kameoka, M., et al. AIDS Res. Hum. Retroviruses 25(10):1005-1011(2009)Li, Q., et al. Nat. Cell Biol. 11(9):1128-1134(2009)

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$ 80.00
Cat# BP12033b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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