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BMPR1B Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O00238
Clone Names 101008251
Peptide ID 101008251
Additional Information
Gene ID 658
Other Names Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, CDw293, BMPR1B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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This gene encodes a member of the bone morphogeneticprotein (BMP) receptor family of transmembrane serine/threoninekinases. The ligands of this receptor are BMPs, which are membersof the TGF-beta superfamily. BMPs are involved in endochondral boneformation and embryogenesis. These proteins transduce their signalsthrough the formation of heteromeric complexes of 2 different typesof serine (threonine) kinase receptors: type I receptors of about50-55 kD and type II receptors of about 70-80 kD. Type II receptorsbind ligands in the absence of type I receptors, but they requiretheir respective type I receptors for signaling, whereas type Ireceptors require their respective type II receptors for ligandbinding. Mutations in this gene have been associated with primarypulmonary hypertension.


Mick, E., et al. J Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ma, Y., et al. J. Exp. Clin. Cancer Res. 29, 85 (2010) :Saetrom, P., et al. Cancer Res. 69(18):7459-7465(2009)

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$ 80.00
Cat# BP12034c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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