|Other Accession||Q9DA37, NP_653261.1|
|Other Names||Sphingomyelin synthase-related protein 1, SMSr, 278-, Ceramide phosphoethanolamine synthase, CPE synthase, Sterile alpha motif domain-containing protein 8, SAM domain-containing protein 8, SAMD8|
|Target/Specificity||The synthetic peptide sequence is selected from aa 53-67 of HUMAN SAMD8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Huitema, K., et al. EMBO J. 23(1):33-44(2004)
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