|Other Names||Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).|
|Cellular Location||Secreted. Cell membrane|
|Tissue Location||Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level)|
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The protein encoded by this gene is a member of the bonemorphogenetic protein (BMP) family and the TGF-beta superfamily.This group of proteins is characterized by a polybasic proteolyticprocessing site which is cleaved to produce a mature proteincontaining seven conserved cysteine residues. The members of thisfamily are regulators of cell growth and differentiation in bothembryonic and adult tissues. Mutations in this gene are associatedwith acromesomelic dysplasia, Hunter-Thompson type; brachydactyly,type C; and chondrodysplasia, Grebe type. These associationsconfirm that the gene product plays a role in skeletal development.
Posthumus, M., et al. Rheumatology (Oxford) 49(11):2090-2097(2010)Rouault, K., et al. Osteoarthr. Cartil. 18(9):1144-1149(2010)Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
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