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GDF5 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P43026
Clone Names 101109052
Additional Information
Gene ID 8200
Other Names Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF5
Synonyms BMP14, CDMP1
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Cellular Location Secreted. Cell membrane
Tissue Location Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level)
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the bonemorphogenetic protein (BMP) family and the TGF-beta superfamily.This group of proteins is characterized by a polybasic proteolyticprocessing site which is cleaved to produce a mature proteincontaining seven conserved cysteine residues. The members of thisfamily are regulators of cell growth and differentiation in bothembryonic and adult tissues. Mutations in this gene are associatedwith acromesomelic dysplasia, Hunter-Thompson type; brachydactyly,type C; and chondrodysplasia, Grebe type. These associationsconfirm that the gene product plays a role in skeletal development.

References

Posthumus, M., et al. Rheumatology (Oxford) 49(11):2090-2097(2010)Rouault, K., et al. Osteoarthr. Cartil. 18(9):1144-1149(2010)Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

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$ 277.78
Cat# BP12038b
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