|Other Names||40S ribosomal protein S19, RPS19|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for pre-rRNA processing and maturation of 40S ribosomal subunits.|
|Cellular Location||Nucleus. Note=Located more specifically in the nucleoli|
|Tissue Location||Higher level expression is seen in the colon carcinoma tissue than normal colon tissue|
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Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 40S subunit. The protein belongsto the S19E family of ribosomal proteins. It is located in thecytoplasm. Mutations in this gene cause Diamond-Blackfan anemia(DBA), a constitutional erythroblastopenia characterized by absentor decreased erythroid precursors, in a subset of patients. Thissuggests a possible extra-ribosomal function for this gene inerythropoietic differentiation and proliferation, in addition toits ribosomal function. Higher expression levels of this gene insome primary colon carcinomas compared to matched normal colontissues has been observed. As is typical for genes encodingribosomal proteins, there are multiple processed pseudogenes ofthis gene dispersed through the genome.
Devlin, E.E., et al. Blood 116(15):2826-2835(2010)Iadevaia, V., et al. Oncogene 29(40):5490-5499(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Nishiura, H., et al. Apoptosis 15(8):966-981(2010)Schuster, J., et al. Blood Cells Mol. Dis. 45(1):23-28(2010)
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