|Other Names||Chemokine XC receptor 1, G-protein coupled receptor 5, Lymphotactin receptor, XC chemokine receptor 1, XCR1, CCXCR1, GPR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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The protein encoded by this gene is a chemokine receptorbelonging to the G protein-coupled receptor superfamily. The familymembers are characterized by the presence of 7 transmembranedomains and numerous conserved amino acids. This receptor is mostclosely related to RBS11 and the MIP1-alpha/RANTES receptor. Ittransduces a signal by increasing the intracellular calcium ionslevel. The viral macrophage inflammatory protein-II is anantagonist of this receptor and blocks signaling. Two alternativelyspliced transcript variants encoding the same protein have beenfound for this gene.
Yamazaki, C., et al. Biochem. Biophys. Res. Commun. 397(4):756-761(2010)Crozat, K., et al. J. Exp. Med. 207(6):1283-1292(2010)Bachem, A., et al. J. Exp. Med. 207(6):1273-1281(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Luttichau, H.R. Virol. J. 5, 50 (2008) :
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