|Other Names||Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase, GGH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.|
|Cellular Location||Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
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Provided below are standard protocols that you may find useful for product applications.
This gene catalyzes the hydrolysis offolylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates bythe removal of gamma-linked polyglutamates and glutamate. [providedby RefSeq].
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Organista-Nava, J., et al. Leuk. Res. 34(6):728-732(2010)Figueiredo, J.C., et al. Cancer Causes Control 21(4):597-608(2010)Dervieux, T., et al. Pharmacogenet. Genomics (2009) In press :
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