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GLMN Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92990 |
|---|---|
| Clone Names | 101008164 |
| Gene ID | 11146 |
|---|---|
| Other Names | Glomulin, FK506-binding protein-associated protein, FAP, FKBP-associated protein, GLMN, FAP48, FAP68, VMGLOM |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GLMN |
|---|---|
| Function | [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a phosphorylated protein that is amember of a Skp1-Cullin-F-box-like complex. The protein isessential for normal development of the vasculature and mutationsin this gene have been associated with glomuvenous malformations,also called glomangiomas. Alternatively spliced variants thatencode different protein isoforms have been described but thefull-length nature of only one has been determined. [provided byRefSeq].
References
Arai, T., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9855-9860(2003)Brouillard, P., et al. Clin. Genet. 63(5):340-351(2003)Krummrei, U., et al. Proc. Natl. Acad. Sci. U.S.A. 100(5):2444-2449(2003)Brouillard, P., et al. Am. J. Hum. Genet. 70(4):866-874(2002)Grisendi, S., et al. J. Biol. Chem. 276(49):46632-46638(2001)
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