SH2D4A Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H788 |
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Clone Names | 101008214 |
Gene ID | 63898 |
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Other Names | SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regulatory subunit 38, SH2D4A, PPP1R38, SH2A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SH2D4A |
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Synonyms | PPP1R38, SH2A |
Function | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T- cell development and function. |
Cellular Location | Cytoplasm. Note=Located at podocyte foot processes. |
Tissue Location | Ubiquitously expressed. Aberrantly expressed in some cancers. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, T., et al. BMB Rep 42(8):516-522(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Lapinski, P.E., et al. J. Immunol. 181(3):2019-2027(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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