|Other Names||SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regulatory subunit 38, SH2D4A, PPP1R38, SH2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.|
|Cellular Location||Cytoplasm. Note=Located at podocyte foot processes.|
|Tissue Location||Ubiquitously expressed. Aberrantly expressed in some cancers.|
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Provided below are standard protocols that you may find useful for product applications.
SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, T., et al. BMB Rep 42(8):516-522(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Lapinski, P.E., et al. J. Immunol. 181(3):2019-2027(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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