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PURB Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96QR8
Clone Names 101008297
Peptide ID 101008297
Additional Information
Gene ID 5814
Other Names Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B, PURB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in myocardium of heart failure patients.
Research Areas
Citations (0)

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This gene product is a sequence-specific, single-strandedDNA-binding protein. It binds preferentially to the single strandof the purine-rich element termed PUR, which is present at originsof replication and in gene flanking regions in a variety ofeukaryotes from yeasts through humans. Thus, it is implicated inthe control of both DNA replication and transcription. Deletion ofthis gene has been associated with myelodysplastic syndrome andacute myelogenous leukemia.


Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ramsey, J.E., et al. Biochemistry 48(27):6348-6360(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP12051b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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