|Other Names||Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes.|
|Tissue Location||Brain and testis.|
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This gene encodes a protein belonging to the raf/milfamily of serine/threonine protein kinases. This protein plays arole in regulating the MAP kinase/ERKs signaling pathway, whichaffects cell division, differentiation, and secretion. Mutations inthis gene are associated with cardiofaciocutaneous syndrome, adisease characterized by heart defects, mental retardation and adistinctive facial appearance. Mutations in this gene have alsobeen associated with various cancers, including non-Hodgkinlymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma,non-small cell lung carcinoma, and adenocarcinoma of lung. Apseudogene, which is located on chromosome X, has been identifiedfor this gene.
Weisbart, R.H., et al. J. Biol. Chem. 285(45):34299-34303(2010)Agaimy, A., et al. Am. J. Surg. Pathol. 34(11):1663-1671(2010)Bruckman, K.C., et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(5):632-637(2010)Sviatoha, V., et al. Anticancer Res. 30(9):3267-3272(2010)Corbo, V., et al. PLoS ONE 5 (9), E12653 (2010) :
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