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Tiparp Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8C1B2 |
|---|---|
| Clone Names | 71113044 |
| Gene ID | 99929 |
|---|---|
| Other Names | TCDD-inducible poly [ADP-ribose] polymerase, ADP-ribosyltransferase diphtheria toxin-like 14, ARTD14, Tiparp |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Tiparp {ECO:0000303|PubMed:11716501, ECO:0000312|MGI:MGI:2159210} |
|---|---|
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP- ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tiparp is a poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
References
Schmahl, J., et al. Genes Dev. 22(23):3255-3267(2008)Schmahl, J., et al. Nat. Genet. 39(1):52-60(2007)Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)Ma, Q. Arch. Biochem. Biophys. 404(2):309-316(2002)Ma, Q., et al. Biochem. Biophys. Res. Commun. 289(2):499-506(2001)
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