SOX3 Antibody (Center P204) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P41225 |
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Clone Names | 71130126 |
Gene ID | 6658 |
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Other Names | Transcription factor SOX-3, SOX3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SOX3 |
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Function | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SOX (SRY-relatedHMG-box) family of transcription factors involved in the regulationof embryonic development and in the determination of the cell fate.The encoded protein may act as a transcriptional regulator afterforming a protein complex with other proteins. Mutations in thisgene have been associated with X-linked mental retardation withgrowth hormone deficiency.
References
Dateki, S., et al. J. Clin. Endocrinol. Metab. 95(8):4043-4047(2010)Sato, Y., et al. Mol. Cell. Biochem. 337 (1-2), 267-275 (2010) :Mojsin, M., et al. Biochem. J. 425(1):107-116(2010)Bleyl, S.B., et al. Am. J. Med. Genet. A 143A (23), 2785-2795 (2007) :Krstic, A., et al. Arch. Biochem. Biophys. 467(2):163-173(2007)
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