|Other Names||Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, SUV420H2, KMT5C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
SUV420H2 and the related enzyme SUV420H1 (MIM 610881)function as histone methyltransferases that specificallytrimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20(K20) (Schotta et al., 2004 [PubMed 15145825]).
Stolk, L., et al. Nat. Genet. (2009) In press :Souza, P.P., et al. BMC Cell Biol. 10, 41 (2009) :Yang, H., et al. J. Biol. Chem. 283(18):12085-12092(2008)Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :Tryndyak, V.P., et al. Cancer Biol. Ther. 5(1):65-70(2006)
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