|Other Names||Thromboxane-A synthase, TXA synthase, TXS, Cytochrome P450 5A1, TBXAS1, CYP5, CYP5A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Platelets, lung, kidney, spleen, macrophages and lung fibroblasts|
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This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.However, this protein is considered a member of the cytochrome P450superfamily on the basis of sequence similarity rather thanfunctional similarity. This endoplasmic reticulum membrane proteincatalyzes the conversion of prostglandin H2 to thromboxane A2, apotent vasoconstrictor and inducer of platelet aggregation. Theenzyme plays a role in several pathophysiological processesincluding hemostasis, cardiovascular disease, and stroke.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Wang, L.H., et al. Prostaglandins Other Lipid Mediat. 68-69, 409-422 (2002) :Tazawa, R., et al. Arch. Biochem. Biophys. 334(2):349-356(1996)Baek, S.J., et al. Gene 173(2):251-256(1996)Wang, L.H., et al. Arch. Biochem. Biophys. 315(2):273-278(1994)
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