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ZNF593 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00488 |
|---|---|
| Clone Names | 80612093 |
| Gene ID | 51042 |
|---|---|
| Other Names | Zinc finger protein 593, Zinc finger protein T86, ZNF593 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZNF593 |
|---|---|
| Synonyms | ZT86 |
| Function | Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547). Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q08004}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q08004} |
| Tissue Location | Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF593 negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
References
Hayes, P.L., et al. Protein Sci. 17(3):571-576(2008)Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)Terunuma, A., et al. Nucleic Acids Res. 25(10):1984-1990(1997)
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