|Other Names||Nuclear pore complex protein Nup88, 88 kDa nucleoporin, Nucleoporin Nup88, NUP88|
|Target/Specificity||The synthetic peptide sequence is selected from aa 344-356 of HUMAN NUP88|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of nuclear pore complex.|
|Cellular Location||Nucleus, nuclear pore complex.|
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Provided below are standard protocols that you may find useful for product applications.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.
Hashizume, C., et al. Mol. Cancer 9, 119 (2010) :
Brustmann, H., et al. Ann Diagn Pathol 13(5):303-307(2009)
Cheng, Y.T., et al. Plant Cell 21(8):2503-2516(2009)
Andres-Hernando, A., et al. J. Biol. Chem. 283(36):25082-25090(2008)
Kodiha, M., et al. Biochim. Biophys. Acta 1783(3):405-418(2008)
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