|Other Names||Serpin B5, Maspin, Peptidase inhibitor 5, PI-5, SERPINB5, PI5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Normal mammary epithelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Kim, J., et al. Tumour Biol. 31(5):471-476(2010)Juengel, E., et al. World J Urol 28(4):465-471(2010)Besgen, P., et al. J. Immunol. 184(9):5392-5402(2010)Fung, C.L., et al. Histopathology 56(3):319-330(2010)Adim, S.B., et al. World J Surg Oncol 8, 22 (2010) :
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