|Other Names||Neutrophil elastase, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.|
|Tissue Location||Bone marrow cells.|
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Provided below are standard protocols that you may find useful for product applications.
Elastases form a subfamily of serine proteases thathydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteins. Theproduct of this gene hydrolyzes proteins within specializedneutrophil lysosomes, called azurophil granules, as well asproteins of the extracellular matrix following the protein'srelease from activated neutrophils. The enzyme may play a role indegenerative and inflammatory diseases by its proteolysis ofcollagen-IV and elastin of the extracellular matrix. This proteindegrades the outer membrane protein A (OmpA) of E. coli as well asthe virulence factors of such bacteria as Shigella, Salmonella andYersinia. Mutations in this gene are associated with cyclicneutropenia and severe congenital neutropenia (SCN). This gene isclustered with other serine protease gene family members,azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3genes are expressed coordinately and their protein products arepackaged together into azurophil granules during neutrophildifferentiation.
Kallquist, L., et al. Exp. Cell Res. 316(19):3182-3196(2010)Rabai, G., et al. Thromb. Res. 126 (2), E94-E101 (2010) :Newburger, P.E., et al. Pediatr Blood Cancer 55(2):314-317(2010)Hayashi, M., et al. J Nippon Med Sch 77(2):80-85(2010)Hector, A., et al. Mediators Inflamm. 2010, 809591 (2010) :
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