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ZEB2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60315 |
|---|---|
| Clone Names | 80703108 |
| Gene ID | 9839 |
|---|---|
| Other Names | Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, SMADIP1, Zinc finger homeobox protein 1b, ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZEB2 (HGNC:14881) |
|---|---|
| Function | Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). |
| Cellular Location | Nucleus. Chromosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the Zfh1family of 2-handed zinc finger/homeodomain proteins. It is locatedin the nucleus and functions as a DNA-binding transcriptionalrepressor that interacts with activated SMADs. Mutations in thisgene are associated with Hirschsprung disease/Mowat-Wilsonsyndrome. Alternatively spliced transcript variants have been foundfor this gene.
References
Kumar, P.A., et al. J. Biol. Chem. 285(41):31148-31156(2010)Li, A., et al. Cancer Res. 70(13):5226-5237(2010)Ohashi, S., et al. Cancer Res. 70(10):4174-4184(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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