|Other Names||Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, SMADIP1, Zinc finger homeobox protein 1b, ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0569, SIP1, ZFHX1B, ZFX1B|
|Function||Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin.|
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The protein encoded by this gene is a member of the Zfh1family of 2-handed zinc finger/homeodomain proteins. It is locatedin the nucleus and functions as a DNA-binding transcriptionalrepressor that interacts with activated SMADs. Mutations in thisgene are associated with Hirschsprung disease/Mowat-Wilsonsyndrome. Alternatively spliced transcript variants have been foundfor this gene.
Kumar, P.A., et al. J. Biol. Chem. 285(41):31148-31156(2010)Li, A., et al. Cancer Res. 70(13):5226-5237(2010)Ohashi, S., et al. Cancer Res. 70(10):4174-4184(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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